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IL-1ra versus IL-1 levels in prostatic fluid from prostatitis patients
1Department of Urology, Nippon Medical School, Chiba, Japan.
Urologia Internationalis
|May 1, 1998
Summary
Low levels of interleukin-1 receptor antagonist (IL-1ra) in prostatic fluid do not appear to cause prolonged nonbacterial prostatitis (NBP). Prostatic fluid analysis revealed insufficient evidence to support this hypothesis in NBP patients.
Area of Science:
- Urology
- Immunology
- Inflammation Research
Background:
- The balance between IL-1ra and IL-1 influences inflammatory responses.
- Leukocytosis in prostatic fluid is observed in prostatitis patients.
Purpose of the Study:
- To investigate if low IL-1ra levels relative to IL-1 beta in prostatic fluid cause prolonged nonbacterial prostatitis (NBP).
Main Methods:
- Analysis of IL-1ra and IL-1 beta levels in prostatic fluid from NBP patients.
- Comparison with levels in acute bacterial prostatitis (ABP) and acute bacterial cystitis cases.
Main Results:
- IL-1 beta was detected in 50% of NBP cases, with only 20% showing slight elevation.
- Average IL-1ra levels in NBP were not significantly lower than in promptly treated ABP patients.
- The IL-1ra/IL-1 beta ratio in NBP was comparable to or higher than in ABP and acute bacterial cystitis cases.
Conclusions:
- Low IL-1ra levels in prostatic fluid are unlikely to be the cause of prolonged nonbacterial prostatitis.
- The IL-1ra/IL-1 beta ratio does not support a role for this imbalance in NBP chronicity.