Detection of benzodiazepine abuse in opiate addicts
Related Experiment Video
Updated: Oct 29, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Abstract:
There is an increasing problem with benzodiazepine co-abuse in the opiate dependent population of Dublin. The importance of early detection of this co-abuse is essential as there is an increased risk of dangerous injecting practices such as sharing of needles and criminality in those who co-abuse benzodiazepines and opiates. This study was carried out in the National Drug Treatment Centre, Dublin. It aims to describe the current difficulties in identifying the co-abuse of short acting benzodiazepines including flunitrazepam in a cohort of opiate dependent patients. Using a sample of those attending the clinic it was discovered that standard methods of urinalysis failed to identify 10% of co-abuse. For those patients whose abuse of flunitrazepam is undetected on screening, clinical interventions which aim to minimise the consequence of the co-abuse and reverse the chaotic drug using patterns fail to be put in place at the earliest possible time.
Related Concept Videos
CNS Depressants: Barbiturates and Benzodiazepines
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Drug Abuse and Addiction: Pharmacological Phenomena
Opioid Analgesics: Morphine and Other Natural Cogeners
Analgesia and Pain Management

