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Related Experiment Video

Updated: Jul 20, 2026

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

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Published on: December 17, 2010

Autoimmune (Hashimoto's) thyroiditis associated with Crohn's disease

S A Shah¹, M A Peppercorn, J A Pallotta

¹Division of Gastroenterology, Brown University School of Medicine, Providence, Rhode Island, USA.

Journal of Clinical Gastroenterology

|May 1, 1998

Summary

Autoimmune thyroiditis, like Hashimoto's, was observed in Crohn's disease patients. This finding suggests autoimmunity plays a role in inflammatory bowel disease (IBD) and highlights the need for thyroid monitoring in IBD patients.

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Published on: March 17, 2023

Area of Science:

Endocrinology
Gastroenterology
Immunology

Background:

Inflammatory bowel disease (IBD) encompasses Crohn's disease and ulcerative colitis.
Thyroid disease has been previously associated primarily with ulcerative colitis.
Autoimmunity is a suspected factor in the development of IBD.

Observation:

Three patients with Crohn's disease were diagnosed with autoimmune (Hashimoto's) thyroiditis.
This represents a newly described association between Crohn's disease and thyroid autoimmunity.

Findings:

The co-occurrence of Hashimoto's thyroiditis in Crohn's disease patients suggests a potential link.
This association supports the hypothesis of autoimmune involvement in the pathogenesis of IBD.

Implications:

Early detection and management of thyroid dysfunction are crucial for IBD patients.
Untreated thyroid issues can exacerbate IBD symptoms and disease progression.
Further research into the autoimmune overlap between IBD and thyroid disorders is warranted.