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Tubes, antibiotic prophylaxis, or watchful waiting: a decision analysis for managing recurrent acute otitis media
1Department of Family Medicine, University of Iowa, Iowa City, IA 52242, USA. george-bergus@uiowa.edu
Insights
For recurrent acute otitis media (AOM), tympanostomy tubes were preferred in the base case. However, the best intervention for children depends on infection frequency, severity, and parental preferences.
Area of Science:
- Pediatric Otolaryngology
- Decision Analysis in Healthcare
- Evidence-Based Medicine
Background:
- Acute otitis media (AOM) is common in young children.
- Tympanostomy tubes and prophylactic antibiotics are primary interventions to reduce AOM.
- Parental preference is a key factor in choosing interventions for recurrent AOM.
Purpose of the Study:
- To develop a decision model evaluating tympanostomy tubes versus prophylactic antibiotics for AOM.
- To identify parental preferences for managing recurrent AOM in children.
Main Methods:
- A decision analysis model was constructed using literature-based probabilities.
- Parental interviews determined outcome disutilities and preferences.
- Sensitivity analyses explored intervention effectiveness and AOM characteristics.
Main Results:
- Parental preferences varied based on anticipated AOM episodes, severity, and intervention ratings.
- In the base case (4 AOM episodes/year), tympanostomy tubes yielded the best outcome.
- Alternative strategies like prophylactic antibiotics or watchful waiting may be preferred under different conditions.
Conclusions:
- Tympanostomy tubes were favored over prophylactic antibiotics in the base case model.
- No single intervention is universally preferred for recurrent AOM due to individual variations.
- Parental values significantly influence the choice of preventive strategy for AOM.
Background:
The two most frequently used options to reduce the occurrence of acute otitis media (AOM) are tympanostomy tubes and prophylactic antibiotics. The goal of this study was to create a decision model to identify which intervention, if any, is preferred from the perspective of parents with young children.
Methods:
We developed a decision analysis model based on probabilities obtained from the literature and outcome disutilities obtained by interviewing parents. These parameters were placed into the model along with the anticipated number of episodes of AOM a child was expected to have in the coming year without intervention. Sensitivity analyses were performed on the effectiveness of the interventions, the disutilities (burdens associated with specific outcomes or interventions) associated with the interventions, and the characteristics of AOM episodes that the child would experience without any intervention.
Results:
Thirty-seven parents with young children were interviewed for this project. The preferred intervention for a child was sensitive to the number of episodes of AOM the child was anticipated to have in the coming year, the percentage of these episodes predicted to be severe, and how parents rated tympanostomy tubes compared with prophylactic antibiotics. In our base case of four episodes of AOM in the coming year (two mild episodes and two severe episodes), we found that tympanostomy tubes resulted in the best average outcome. Under different patient conditions, however, the preferred strategy could be either the use of prophylactic antibiotics or watchful waiting.
Conclusions:
In our base case, the model suggested that tympanostomy tubes were preferable to prophylactic antibiotics. However, there is no single preferred preventive intervention for all children with recurrent AOM because of variation in the character of infections and the values parents give to the potential outcomes.