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Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology
J G Richards1, J Saura, J M Luque
1Pharmaceuticals Division, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Journal of Neural Transmission. Supplementum
|June 13, 1998
Abstract:
The present report reviews recent advances in mapping the cellular sites of synthesis and catalytic activity, as well as age- and disease-related changes of monoamine oxidases A and B in the brain. A transgenic model of oxidative stress is also described. The relevance of these findings for the physiological and pathophysiological roles of monoamine oxidases is briefly discussed.