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"Add-back" therapy for endometriosis in adolescents
J N Lubianca1, C M Gordon, M R Laufer
1Department of Surgery, Children's Hospital, Boston, Massachusetts 02115, USA.
The Journal of Reproductive Medicine
|June 6, 1998
Summary
Gonadotropin-releasing hormone agonists (GnRH-a) with add-back therapy may help adolescents with endometriosis. However, more research is needed to determine the optimal steroid dosage for long-term use and effects on bone mass.
Area of Science:
- Reproductive Endocrinology
- Pediatric Gynecology
Background:
- Endometriosis affects adolescents, often requiring long-term management.
- Conventional therapies may be insufficient for some adolescent patients.
Purpose of the Study:
- To review the impact of GnRH agonists (GnRH-a) on bone mass in adolescents.
- To explore "add-back" therapy options for GnRH-a in adolescents with endometriosis refractory to conventional treatment.
Main Methods:
- Literature research was conducted.
Main Results:
- Specific studies on GnRH-a plus add-back therapy in adolescents are lacking.
- The ideal dosage of add-back sex steroids for adolescents has not been established.
Conclusions:
- GnRH-a with add-back therapy is a potential option for adolescents with endometriosis unresponsive to standard treatments.
- Further research is required to determine optimal steroid dosages and long-term effects, particularly on bone health.