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Late asthmatic response in exercise-induced asthma

S K Chhabra1, U C Ojha

  • 1Department of Cardiorespiratory Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, India.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|May 16, 1998
PubMed
Summary

A late asthmatic response genuinely occurs after exercise-induced asthma. However, clinical or physiological factors do not predict its occurrence in patients with asthma.

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Area of Science:

  • Pulmonary Medicine
  • Allergy and Immunology

Background:

  • Controversy exists regarding late asthmatic responses following exercise-induced asthma.
  • Some studies suggest genuine late responses, while others attribute them to medication withdrawal.

Purpose of the Study:

  • To investigate the genuine occurrence of late asthmatic responses in exercise-induced asthma.
  • To identify factors influencing the occurrence of these late responses.

Main Methods:

  • Sixteen stable asthmatic patients underwent standardized exercise challenges.
  • Spirometry (FEV1) was measured before, during, and for 7 hours post-exercise.
  • A non-exercise control day was used for comparison.

Main Results:

  • 50% of subjects exhibited a late asthmatic response (fall >10% in FEV1) 3-8 hours post-exercise.

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  • Late responses were significantly greater than spontaneous lung function decline.
  • No clinical or physiological factors predicted dual responders.

    • Conclusions:

    • Late asthmatic responses are a genuine phenomenon in exercise-induced asthma.
    • Predicting the occurrence of late asthmatic responses is not currently possible based on clinical or physiological factors.