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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Malignant cough equivalent asthma: definition and case reports

M M Millar1, K G McGrath, R Patterson

  • 1Department of Medicine, and the Ernest S. Bazley Asthma and Allergic Diseases Center of Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Illinois 60611, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|May 16, 1998
PubMed
Summary

Malignant cough equivalent asthma causes severe chronic cough, often disrupting sleep and daily life. This condition requires higher oral corticosteroid doses for initial management.

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Area of Science:

  • Pulmonology
  • Allergy and Immunology

Background:

  • Cough equivalent asthma is a common cause of chronic cough, typically managed with corticosteroids.
  • Oral corticosteroids are used for diagnosis and initial treatment, while inhaled corticosteroids are for maintenance.
  • Severe cases may necessitate escalated oral corticosteroid doses for initial control, termed malignant cough equivalent asthma.

Observation:

  • Two cases of chronic cough, severe enough to disrupt sleep and daily activities, are presented.
  • One patient experienced an emergency room visit and hospitalization due to the severity of the cough.
  • Standard treatments for cough equivalent asthma were ineffective, prompting consideration of a more severe form.

Findings:

  • Malignant cough equivalent asthma is characterized by chronic cough significantly impacting sleep and daily life.
  • This severe asthma variant can lead to emergency room visits or hospitalization.
  • Effective initial management involves escalated doses of oral corticosteroids.

Implications:

  • Physicians should consider malignant cough equivalent asthma in patients with severe, disruptive chronic cough unresponsive to standard therapy.
  • Prompt recognition and appropriate corticosteroid escalation can improve patient outcomes.
  • This condition highlights the spectrum of cough equivalent asthma severity and management needs.