Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute 2,4-dichlorophenoxyacetic acid intoxication in broiler chicks

M S Morgulis1, G H Oliveira, M L Dagli

  • 1Research Center for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine, University of São Paulo, SP, Brazil.

Poultry Science
|June 20, 1998
PubMed
Summary

Acute exposure to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in chicks caused dose-dependent muscle and kidney damage. The lethal dose 50% (LD50) was determined to be 420 mg/kg body weight.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RIFM fragrance ingredient safety assessment, 2-phenoxyethanol, CAS Registry Number 122-99-6.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2019
Same author

RIFM fragrance ingredient safety assessment, 2-tert-butylcyclohexyl propionate, CAS Registry Number 40702-13-4.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2019
Same author

RIFM fragrance ingredient safety assessment, hexyl butyrate, CAS Registry Number 2639-63-6.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2019
Same author

RIFM fragrance ingredient safety assessment, diphenyl ether, CAS Registry Number 101-84-8.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2019
Same author

RIFM fragrance ingredient safety assessment, methyl 2-nonenoate, CAS Registry Number 111-79-5.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2019
Same author

RIFM fragrance ingredient safety assessment, 3-methylpentyl 2-methylisocrotonate, CAS Registry Number 53082-58-9.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2019

Area of Science:

  • Veterinary Toxicology
  • Environmental Health
  • Agricultural Science

Background:

  • 2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide.
  • Understanding its acute toxicity in avian species is crucial for environmental and agricultural safety.
  • Chicks serve as a relevant model for studying herbicide effects in poultry.

Purpose of the Study:

  • To determine the acute oral toxicity of 2,4-D in chicks.
  • To identify clinical, laboratory, and histopathological indicators of 2,4-D intoxication.
  • To establish the lethal dose 50% (LD50) for 2,4-D in this species.

Main Methods:

  • Chicks were orally administered varying doses of 2,4-D (100-600 mg/kg BW).
  • Toxicity was assessed through clinical observations, serum biochemistry (CK, AP, UA, CR, TP, AST, ALT), and histopathology.

Related Experiment Videos

  • Herbicide levels in serum were analyzed using chromatography.

    • Main Results:

    • 2,4-D exposure decreased motor activity, induced muscle weakness, and reduced weight gain.
    • Elevated serum CK, AP, UA, CR, and TP levels were observed, indicating tissue damage.
    • Histopathology revealed hepatic, renal, and intestinal lesions, with primary damage to kidney and muscle tissues.

    Conclusions:

    • Acute 2,4-D intoxication in chicks primarily affects muscle and kidney tissues.
    • The observed toxic effects are dose- and time-dependent and reversible.
    • The oral LD50 of 2,4-D in chicks was determined to be 420 mg/kg BW.