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Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix
E Orion1, E Paulsen, K E Andersen
1Department of Dermatology, Tel-Aviv Medical Center, Israel.
Contact Dermatitis
|June 20, 1998
Summary
Sesquiterpene lactone (SL) mix is a safe but insufficient screen for Compositae allergy. Parthenolide is not ideal as a supplementary screen to SL mix but can be a useful standalone test.
Area of Science:
- Dermatology
- Allergology
- Plant Chemistry
Background:
- Sesquiterpene lactone (SL) mix is recognized as a safe, yet inadequate, screening tool for Compositae allergy.
- Compositae-derived allergens are a common cause of allergic contact dermatitis.
Purpose of the Study:
- To evaluate the efficacy of parthenolide as a supplementary screening agent for Compositae allergy when used alongside the standard SL mix.
- To assess the potential of parthenolide as a standalone screening test for Compositae allergy.
Main Methods:
- A study involving 2244 patients was conducted across two Danish dermatology departments.
- Patients were patch tested with both the standard SL mix and purified parthenolide as part of their routine screening.
- The study compared the positivity rates between the SL mix and parthenolide.
Main Results:
- Approximately 2% of the 2244 patients tested showed a positive reaction to the SL mix.
- Between 73% and 75% of patients who were positive to the SL mix also reacted positively to parthenolide.
- Parthenolide demonstrated a significant overlap in positive reactions with the SL mix.
Conclusions:
- Parthenolide is not recommended as a supplementary screening agent to the sesquiterpene lactone mix for Compositae allergy.
- Parthenolide may serve as a viable standalone screening agent for Compositae allergy, particularly when the SL mix is unavailable.