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Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment
P Scalfaro1, J J Chesaux, P A Buchwalder
1Division of Neonatology, University Hospital, Lausanne, Switzerland.
Intensive Care Medicine
|May 5, 1998
Abstract:
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this longterm treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.