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Ageing, nutritional status and immune response

K Buzina-Suboticanec1, R Buzina, A Stavljenic

  • 1Institute of Public Health, Zagreb, Croatia.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|May 5, 1998
PubMed
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Vitamin supplementation improved immune function in the elderly, reversing age-related decline in immune response. This study highlights nutrition

Area of Science:

  • Gerontology
  • Immunology
  • Nutritional Science

Background:

  • Age-related decline in immune function (immunosenescence) is a significant concern in elderly populations.
  • Elderly individuals often exhibit deficiencies in essential vitamins (C, E, riboflavin, pyridoxine) and minerals (iron, zinc), impacting immune health.
  • Low serum vitamin levels are prevalent in elderly populations, necessitating research into nutritional interventions.

Purpose of the Study:

  • To investigate the impact of vitamin supplementation on age-related immune function decline in elderly individuals.
  • To assess whether correcting vitamin deficiencies can restore immunocompetence in older adults.

Main Methods:

  • A study involving 72 subjects aged 60-89 years residing in elderly care facilities.

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  • Immune function was assessed using the delayed cutaneous hypersensitivity (DCH) test with 7 antigens.
  • Intervention group received vitamin supplementation for 10 weeks; a placebo group received no active treatment.

    • Main Results:

    • A significant, age-related decline in DCH test results was observed (p < 0.01).
    • Vitamin supplementation significantly improved vitamin biochemical parameters and normalized the age-related decline in DCH response (P > 0.05).
    • The placebo group showed no significant changes in DCH, indicating the effects were due to supplementation.

    Conclusions:

    • Vitamin supplementation can effectively counteract the age-related decline in immune function among the elderly.
    • Nutritional status is a critical factor influencing immunocompetence in older adults.
    • Targeted vitamin interventions may be a viable strategy to enhance immune health in the aging population.