Related Experiment Video
Updated: Aug 23, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
Published on: October 10, 2012
Animal defensive reactions as a model for trauma-induced dissociative reactions
E R Nijenhuis1, J Vanderlinden, P Spinhoven
1Department of Psychiatry, Vrije Universiteit, Amsterdam, The Netherlands.
Abstract:
Patients with complex dissociative disorders remain in alternating psychophysiological states which are discrete, discontinuous, and resistant against integrative tendencies. In this contribution, a parallel is drawn between animal defensive and recuperative states that are evoked in the face of severe threat and the characteristic responses of dissociative disorder patients as displayed in major dissociative states. Empirical data and clinical observations seem to be supportive of the idea that there are similarities between freezing, concomitant development of analgesia and anesthesia, and acute pain in threatened animals and severely traumatized human beings.
More Related Videos
Related Concept Videos
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Traumatic Memory
Post-traumatic Stress Disorder
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Dissociative Disorders
Dissociative Fugue
A hallmark feature of dissociative disorders is the dissociative fugue...
Dissociative Identity Disorder
Dissociative Amnesia

