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Pattern shift visual evoked potential screening for HBO2 in mild-to-moderate carbon monoxide poisoning
1Marquette General Hospital Regional Medical Center, Department of Hyperbaric Medicine, Michigan, USA.
Summary
Pattern shift visual evoked potential (PSVEP) testing did not effectively identify brain dysfunction in acute carbon monoxide (CO) poisoning. PSVEP latencies were insensitive for guiding treatment decisions in mild-to-moderate CO poisoning cases.
Area of Science:
- Neurology
- Toxicology
- Neurophysiology
Background:
- Carbon monoxide (CO) poisoning can cause brain dysfunction.
- Objective, rapid tests are needed for acute CO poisoning assessment.
- Pattern shift visual evoked potential (PSVEP) is a potential objective measure.
Purpose of the Study:
- To evaluate PSVEP N75 and P100 latencies as an objective test for brain dysfunction in acute CO poisoning.
- To compare PSVEP with the standard CO Neuropsychological Screening Battery (CONSB).
- To assess the utility of PSVEP in guiding treatment decisions (hyperbaric vs. normobaric oxygen).
Main Methods:
- 11 patients with acute mild-to-moderate CO poisoning were studied within 6 hours.
- PSVEP N75 and P100 latencies were measured.
- PSVEP results were compared with CONSB.
- Measurements were repeated after normobaric oxygen (NBO2) or hyperbaric oxygen (HBO2) therapy.
Main Results:
- Only one patient showed significantly abnormal initial PSVEP latencies.
- This patient had clinically mildest poisoning and a normal CONSB.
- Abnormal PSVEP latencies did not normalize after NBO2 treatment in this patient.
Conclusions:
- PSVEP latencies were not a sensitive screening tool for acute CO poisoning.
- PSVEP was not effective in decision-making for oxygen therapy in this patient group.