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[Tetrapyrroles: diversity, biosynthesis, biotechnology]

V Ia Bykhovskiĭ1, N I Zaĭtseva, A A Eliseev

  • 1Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.

Prikladnaia Biokhimiia I Mikrobiologiia
|May 5, 1998
PubMed
Summary

This review covers tetrapyrrole metabolism and biotechnology, including new pigments and biosynthesis pathways. 5-Aminolevulinic acid shows potential as an anticancer treatment.

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Area of Science:

  • Biochemistry
  • Biotechnology
  • Organic Chemistry

Context:

  • Tetrapyrroles are vital pigments and cofactors in biological systems.
  • Understanding their biosynthesis and properties is crucial for various applications.
  • Recent discoveries have expanded the known diversity of tetrapyrrole structures.

Purpose:

  • To review the metabolism and biotechnology of tetrapyrroles.
  • To discuss the biosynthesis of key functional tetrapyrroles (hemes, chlorophylls, corrinoids, siroheme, methanogenesis factor F430).
  • To explore biotechnological production methods for porphyrins and corrinoids.

Summary:

  • The review details the structures and properties of newly discovered tetrapyrrole pigments.
  • It elaborates on the biosynthetic pathways of essential tetrapyrroles.

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  • Biotechnological approaches for producing porphyrins and corrinoids are examined.

    • Impact:

    • Highlights 5-Aminolevulinic acid as a potential anticancer agent.
    • Provides insights into the biotechnological production of valuable tetrapyrrole compounds.
    • Contributes to the understanding of tetrapyrrole diversity and function.