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Published on: November 15, 2013
Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol
M A Eldon1, B A Underwood, E J Randinitis
1Department of Clinical Pharmacology, Parke-Davis, Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, USA.
Abstract:
Anticonvulsants that induce hepatic metabolism increase clearance of oral contraceptive hormones and thereby cause contraceptive failure. Gabapentin is not metabolized in humans and has little liability for causing metabolic-based drug-drug interactions. In healthy women receiving 2.5 mg norethindrone acetate and 50 microg ethinyl estradiol daily for three consecutive menstrual cycles, concurrent gabapentin administration did not alter the steady-state pharmacokinetics of either hormone. Thus, gabapentin is unlikely to cause contraceptive failure.
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