Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human transfer factor: effects on lymphocyte transformation

D R Burger, A A Vandenbark, P Finke

    Journal of Immunology (Baltimore, Md. : 1950)
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of soil process formalisms and forcing factors on simulated organic carbon depth-distributions in soils.

    The Science of the total environment·2018
    Same author

    [Why history of medicine should remain part of the medical curriculum].

    Deutsche medizinische Wochenschrift (1946)·2011
    Same author

    Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease.

    Mucosal immunology·2010
    Same author

    Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis.

    Journal of neuroimmunology·2010
    Same author

    Legionella-induced sudden hearing loss: a rare complication.

    Infection·2009
    Same author

    Mothers with a history of abuse tend to show more impulsiveness.

    Child abuse & neglect·2009
    Same journal

    Optineurin restrains IL-17-associated neuroinflammation in trigeminal ganglia to preserve sensory function after ocular HSV-1 infection.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    Crystal structure and immune single-cell atlas provide insights into the functional divergence of type I IFNs in fish.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    Complement C3 deficiency increases the effector and cytotoxic functions of NK cells and suppresses tumor growth.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    FTR85 negatively regulates type I IFN antiviral signaling pathway by promoting K48-linked polyubiquitination of IRF3.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    Same journal

    An MR1-specific nanobody capable of blocking MR1T cell activation.

    Journal of immunology (Baltimore, Md. : 1950)·2026
    See all related articles

    Transfer factor (TF) preparations exhibit varied effects on lymphocyte responses. While some TF components can stimulate or inhibit lymphocyte transformation, they cannot activate naive lymphocytes to respond to specific antigens.

    Area of Science:

    • Immunology
    • Cellular Immunology

    Background:

    • Transfer factor (TF) is a substance that can transfer cell-mediated immunity.
    • The immunomodulatory effects of TF preparations on lymphocyte proliferation are not fully understood.

    Purpose of the Study:

    • To investigate the effects of 57 different transfer factor (TF) preparations on mitogen- and antigen-induced lymphocyte transformation.
    • To determine if TF can activate naive lymphocytes.

    Main Methods:

    • Lymphocyte transformation assays were performed using various mitogens (PHA, ConA, PWM) and specific antigens (KLH).
    • The effects of 57 TF preparations on lymphocyte proliferation were assessed.
    • Correlation between antigen responsiveness and TF augmentation was analyzed.

    Main Results:

    Related Experiment Videos

    • Nine TF preparations showed low mitogenic activity.
    • Most TF preparations did not affect PHA-induced lymphocyte transformation, with some showing augmentation or suppression.
    • Most TF preparations suppressed ConA stimulation but augmented the PWM response.
    • A positive correlation was observed between antigen responsiveness and TF augmentation of antigen-induced lymphocyte transformation (p < 0.005).
    • TF could not stimulate antigen-unresponsive cultures.

    Conclusions:

    • TF preparations contain both stimulatory and inhibitory components.
    • TF is not capable of activating naive lymphocytes to undergo antigen-specific transformation.
    • The efficacy of TF in modulating immune responses may depend on the recipient's existing antigen responsiveness.