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Changes in peripheral hormone levels after therapeutic abortion

D M Saunders, I M Kelso, J G Grudzinskas

European Journal of Obstetrics, Gynecology, and Reproductive Biology

|February 1, 1978

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Following therapeutic abortion, progesterone and human chorionic gonadotropin (hCG) levels decreased rapidly, while 17 alpha-OH progesterone levels remained elevated longer, suggesting corpus luteum involvement.

Area of Science:

Reproductive Endocrinology
Maternal-Fetal Medicine
Endocrinology

Background:

Hormonal changes after pregnancy termination are critical for understanding reproductive physiology.
Key hormones such as progesterone, 17 alpha-OH progesterone, human placental lactogen (hPL), and beta-subunit human chorionic gonadotropin (hCG) play vital roles during pregnancy.

Purpose of the Study:

To investigate the dynamic changes in plasma hormone levels in women within 24 hours after therapeutic abortion.
To compare the clearance rates of progesterone, 17 alpha-OH progesterone, hPL, and beta-subunit hCG post-abortion.

Main Methods:

Blood samples were collected from women over a 24-hour period following therapeutic abortion.
Plasma concentrations of progesterone, 17 alpha-OH progesterone, hPL, and beta-subunit hCG were quantified.

Keywords:

Abortion, Induced Australia Biology Blood Proteins Clinical Research Developed Countries Endocrine System Europe Family Planning Fertility Control, Postconception Gonadotropins Gonadotropins, Chorionic Hemic System Hormones Northern Europe Oceania Physiology Postabortion Progestational Hormones Progesterone Reproduction Research Methodology Scotland United Kingdom

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Main Results:

Progesterone, hPL, and hCG levels exhibited a rapid decline after abortion.
17 alpha-OH progesterone levels decreased at a slower rate compared to progesterone, hPL, and hCG.
hPL levels dropped significantly within 4 hours, while hCG levels remained relatively stable, indicating differences in hormone half-lives.

Conclusions:

The slower decline of 17 alpha-OH progesterone suggests its primary synthesis may occur in the corpus luteum.
The sustained hCG levels might indicate a prolonged effect on corpus luteum function.
Differential hormone half-lives explain the observed variations in plasma concentrations post-abortion.