Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and degree of
J Regnström1, S Jovinge, P Båvenholm
1Department of Medicine and King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden. jur@inst.med.ks.se
Insights
Helicobacter pylori (HP) infection was not more common in patients with coronary artery disease (CAD) than in controls. HP infection is not linked to inflammation, lipids, or CAD progression, and is not a CAD risk factor.
Area of Science:
- Cardiology
- Infectious Diseases
- Epidemiology
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- The role of chronic infections, such as Helicobacter pylori (HP), as a potential risk factor for CAD remains under investigation.
- Inflammatory markers and lipid profiles are established contributors to CAD pathogenesis.
Purpose of the Study:
- To determine the prevalence of chronic HP infection in patients with established CAD compared to healthy controls.
- To investigate the association between HP infection and key inflammatory parameters and lipid concentrations.
- To assess the impact of HP infection on the degree and progression of CAD.
Main Methods:
- A case-control study combined with a prospective angiographic study.
- 92 male patients with previous myocardial infarction and 95 sex-matched healthy controls were analyzed.
- HP seropositivity, inflammatory markers (fibrinogen, TNF-alpha, orosomucoid), lipid concentrations, and coronary angiography data were assessed.
Main Results:
- The study population exhibited a low prevalence of HP seropositivity.
- No significant difference in HP seropositivity was observed between patients with CAD and healthy controls (42.2% vs. 32.6%).
- HP infection showed no association with increased inflammatory parameters, lipid levels, or the degree and progression of CAD over 5 years.
Conclusions:
- Chronic Helicobacter pylori infection is not associated with inflammatory markers or lipid concentrations in patients with coronary artery disease.
- Helicobacter pylori infection could not be confirmed as a risk factor for the development or progression of coronary artery disease.
Objectives:
To determine the prevalence of chronic infection with Helicobacter pylori (HP) in patients with established coronary artery disease (CAD) and in healthy controls. Furthermore, to investigate whether HP infection is associated with inflammatory parameters, lipid concentrations and degree and progression of CAD.
Design:
A case-control study combined with a prospective angiographic study.
Setting:
Stockholm Metropolitan Area, Sweden.
Patients And Methods:
A material consisting of 92 young men aged 40.9 +/- 3.2 (mean +/- SD) years, with previous myocardial infarction and documented coronary atherosclerosis, and 95 healthy sex-matched controls, aged 43.2 +/- 3.0 (mean +/- SD) years, with similar socio-economic status and ethnic background was analysed for the prevalence of HP seropositivity, plasma concentrations of the inflammatory parameters fibrinogen, tumour necrosis factor alpha and orosomucoid, and serum concentrations of lipids. The impact of HP seropositivity on degree and progression of CAD, as assessed by quantitative coronary angiography, was also determined.
Results:
The study population of mainly Scandinavian origin had a low prevalence of HP seropositivity in comparison with previously published European populations. No significant increase in HP seropositivity was found in patients compared with controls (42.2 vs. 32.6%). Furthermore, HP infection was not associated with increased levels of inflammatory parameters, lipid concentrations or with degree of angiographically determined CAD at baseline, or progression of CAD and clinical events over 5 years.
Conclusions:
HP infection is not associated with inflammatory parameters and lipid concentrations and could not be confirmed as a risk factor for CAD.
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