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Related Experiment Videos

Headache in systemic lupus erythematosus: a controlled study

P P Sfikakis1, D D Mitsikostas, M N Manoussakis

  • 1Department of Propedeutic Medicine, Laikon Hospital, Athens University Medical School, Greece.

British Journal of Rheumatology
|May 5, 1998
PubMed
Summary
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Headaches are not specifically linked to systemic lupus erythematosus (SLE) severity or expression. Most headaches in SLE patients were common types like tension headaches, not unique lupus headaches.

Area of Science:

  • Rheumatology
  • Neurology
  • Immunology

Background:

  • Headaches are often considered a characteristic symptom of systemic lupus erythematosus (SLE).
  • The term 'lupus headache' implies a specific link between headache and SLE activity.

Purpose of the Study:

  • To investigate the prevalence and characteristics of headaches in patients with SLE.
  • To determine if headache is specifically related to SLE expression, severity, or neurological involvement.

Main Methods:

  • A questionnaire was used to assess headache characteristics in 78 SLE patients and 89 healthy controls.
  • SLE clinical features, neurological manifestations, disease severity, and autoantibody profiles were correlated with headache presence.

Main Results:

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  • Headache prevalence (32%) was similar in SLE patients and healthy individuals (30%).
  • No significant differences were found in headache frequency, family history, or analgesic need between groups.
  • Headache type, presence, or severity did not correlate with SLE features, autoantibodies, or predict neurological complications like seizures or psychosis.

Conclusions:

  • Headache is not a specific manifestation or indicator of SLE severity.
  • Diagnosing severe headaches as SLE-related without other neurological signs may overestimate disease activity.
  • Anxiety and depression frequently co-occurred with headaches in SLE patients.