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Related Experiment Videos

Progressive decrease of CD8high+ CD28+ CD57- cells with ageing

J Merino1, M A Martínez-González, M Rubio

  • 1Department of Immunology, Clínica Universitaria, University of Navarra, Pamplona, Spain.

Clinical and Experimental Immunology
|May 5, 1998
PubMed
Summary
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Ageing leads to reduced CD28 expression and increased CD57 expression on CD8+ T cells, impacting T cell responsiveness. These changes are primarily driven by age, with cytomegalovirus (CMV) having a lesser influence.

Area of Science:

  • Immunology
  • Gerontology
  • T cell biology

Background:

  • T cell responsiveness to CD28 costimulation declines with age.
  • CD8+ T lymphocytes play a crucial role in adaptive immunity.
  • Age-related immune changes, or immunosenescence, affect T cell function.

Purpose of the Study:

  • To investigate the hypothesis that decreased CD28 expression on CD8+ T cells contributes to age-related T cell dysfunction.
  • To analyze the expression of CD28 and CD57 on CD8+ T cells in relation to age and cytomegalovirus (CMV) carrier status.

Main Methods:

  • Analysis of CD28 and CD57 expression on CD8+ T lymphocytes from 67 healthy individuals aged 15-69 years.
  • Statistical analysis, including multivariate analysis, to assess the independent effects of age and CMV status.

Related Experiment Videos

  • Evaluation of the mutual exclusivity of CD28 and CD57 expression.

    • Main Results:

    • A significant age-dependent decrease in CD28 expression and a significant increase in CD57 expression on CD8+ T cells were observed.
    • CD28 and CD57 expression were found to be mutually exclusive.
    • Multivariate analysis indicated that the decrease in CD28+ CD57- cells was primarily associated with age, while the increase in CD28- CD57+ cells was influenced by both age and CMV status, predominantly age.

    Conclusions:

    • Ageing is associated with a progressive loss of CD28 expression and a reciprocal increase in CD57 expression on CD8+ T cells.
    • These phenotypic changes in CD8+ T cells are likely linked to lifelong cumulative antigenic stimulation.
    • The findings suggest a mechanism for age-related decline in T cell-mediated immunity.