Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Therapeutic angiogenesis

J M Isner¹, A Takayuki

¹Department of Medicine (Cardiology), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA. jisner@opal.tufts.edu

Frontiers in Bioscience : a Journal and Virtual Library

|May 6, 1998

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Persistently increased expression of the transforming growth factor-β1 gene in human vascular restenosis: Analysis of 62 patients with one or more episode of restenosis.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015

Same author

Evaluation of angiogenesis.

Methods in molecular medicine·2011

Same author

Use of human tissue specimens obtained by directional atherectomy to study restenosis.

Trends in cardiovascular medicine·2011

Same author

Therapeutic angiogenesis in critical limb and myocardial ischemia.

Journal of interventional cardiology·2002

Same author

Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication.

Vascular medicine (London, England)·2002

Same author

Bone marrow as a source of endothelial cells for natural and iatrogenic vascular repair.

Annals of the New York Academy of Sciences·2002

Same journal

The CD44 protein family: roles in embryogenesis and tumor progression.

Frontiers in bioscience : a journal and virtual library·2017

Same journal

Four varieties of voltage-gated proton channels.

Frontiers in bioscience : a journal and virtual library·2017

Same journal

Optical spectroscopy of breast biopsies and human breast cancer xenografts in nude mice.

Frontiers in bioscience : a journal and virtual library·2017

Same journal

Action of polypeptide growth factors in colon cancer; development of new therapeutic approaches.

Frontiers in bioscience : a journal and virtual library·2017

Same journal

Sialomucin complex in tumors and tissues.

Frontiers in bioscience : a journal and virtual library·2017

Same journal

The DCC protein -- neural development and the malignant process.

Frontiers in bioscience : a journal and virtual library·2017

See all related articles

Therapeutic angiogenesis uses growth factors to stimulate new blood vessel growth in ischemic tissues. This approach offers a novel treatment for cardiovascular disease by enhancing collateral circulation.

Area of Science:

Cardiovascular Science
Regenerative Medicine
Molecular Biology

Background:

Therapeutic angiogenesis is crucial for tissue survival during ischemia.
Endogenous angiogenesis can be suboptimal for organ function.
Angiogenic cytokines offer a novel therapeutic strategy for cardiovascular disease.

Purpose of the Study:

To review mechanisms of endogenous therapeutic angiogenesis.
To explore strategies for augmenting angiogenic responses.
To examine collateral blood vessel development in ischemic tissues.

Main Methods:

Review of existing literature on angiogenesis.
Analysis of embryonic vascular development paradigms.
Examination of principles from pathologic neovascularization studies.

Related Experiment Videos

Main Results:

Angiogenic cytokines act as mitogens for endothelial cells.
Cytokines selectively promote neovascularization in ischemic tissues.
Strategies exist to augment endogenous angiogenic capacity.

Conclusions:

Therapeutic angiogenesis is a vital survival mechanism.
Supplemental angiogenic cytokines can improve collateral development.
Understanding angiogenesis mechanisms is key for cardiovascular disease treatment.