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Updated: Jul 2, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

[A case of expanding pulmonary aspergilloma]

Y Nakagawa1, K Shimazu, M Ebihara

  • 1Department of Internal Medicine, National Kumamoto South Hospital, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi
|May 6, 1998
PubMed

Insights

A 60-year-old woman developed semi-invasive pulmonary aspergillosis. This condition progressed from an aspergilloma in a pre-existing tuberculosis cavity, invading the surrounding lung tissue.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Radiology

Background:

  • A 60-year-old female with a history of pulmonary tuberculosis presented with a cavitary lesion in the right upper lung.
  • Radiographic findings over 16 years showed the development and progression of a fungus ball within the cavity.

Observation:

  • Initial chest radiographs in 1980 revealed a small cavitary lesion. By 1984, a fungus ball was noted with pleural thickening.
  • By 1994, the fungus ball's margins became ill-defined with surrounding infiltrative shadows, and Aspergillus antigen tests were positive with elevated serum toxins.
  • Radiographs in 1996 demonstrated substantial enlargement of the fungus ball.

Findings:

  • The case is diagnosed as semi-invasive pulmonary aspergillosis.
  • Progression occurred via direct invasion from an aspergilloma into the adjacent cavitary wall.

Implications:

  • This case highlights the potential for aspergilloma to evolve into semi-invasive pulmonary aspergillosis in patients with prior lung cavities.
  • Early recognition and monitoring of changes in aspergilloma are crucial for timely diagnosis and management of invasive fungal infections.

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