Related Experiment Video
Updated: May 4, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 10, 2014
[Combined antiretroviral therapy for prevention of vertical HIV-1 transmission]
E Casas1, M Gómez-Cano, M Adrados
1Servicio de Medicina Interna, Hospital Príncipe de Asturias, Alcalá de Henares, Madrid.
Abstract:
A 25-year old woman with rapid HIV disease progression had been receiving zidovudine (ZDV) for two years, when she became pregnant. She had a high viral load and carried out zidovudine-resistant viral strains. For these reasons, and with the main objective to maximally reduce viremia, the association of DDI to ZDV was introduced a few weeks before delivery. The virological follow-up for one year has confirmed the lack of HIV infection in the child. Combined antiretroviral therapy during the last weeks of pregnancy might be considered for the prevention of vertical transmission of HIV in cases of high risk of newborn infection, without adding relevant toxicity.
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