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Related Experiment Videos

Mast cell count in surgically resected appendices

R Naik1, R J Gowda, M R Pai

  • 1Department of Pathology, Kasturba Medical College, Mangalore.

Journal of the Indian Medical Association
|May 6, 1998
PubMed
Summary
This summary is machine-generated.

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Mast cell counts in the appendix differ by location and age. Acute appendicitis significantly reduces mast cells, while subacute cases show intermediate levels.

Area of Science:

  • Gastroenterology
  • Immunology
  • Pathology

Background:

  • Mast cells are immune cells found in various tissues, including the gastrointestinal tract.
  • Their role in appendiceal physiology and pathology is not fully understood.
  • Appendicitis involves inflammation of the appendix, potentially affecting resident immune cells.

Purpose of the Study:

  • To investigate mast cell distribution in the human appendix.
  • To compare mast cell counts in normal versus inflamed appendices.
  • To explore the influence of age and appendicitis severity on mast cell populations.

Main Methods:

  • Histological examination of 200 appendix specimens.
  • Quantification of mast cells in mucosal and submucosal layers.

Related Experiment Videos

  • Comparison of mast cell counts based on appendicitis status and patient age.

    • Main Results:

    • In normal appendices, mucosal mast cell counts (mean 47.63/sq mm) were higher than submucosal counts (mean 44.27/sq mm).
    • Higher mean mucosal mast cell counts were observed in patients younger than 15 and older than 46 years.
    • Both mucosal and submucosal mast cell counts were decreased in acute appendicitis.
    • Subacute appendicitis showed intermediate mast cell counts between normal and acute conditions.

    Conclusions:

    • Appendiceal mast cell distribution varies between mucosal and submucosal layers.
    • Age influences mucosal mast cell density.
    • Mast cell depletion is associated with acute appendicitis, suggesting a role in the inflammatory process.