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Immunopotentiating activity of septilin
V Praveenkumar1, R Kuttan, G Kuttan
1Amala Cancer Research Centre, Amala Nagar, Thrissur, India.
Indian Journal of Experimental Biology
|May 6, 1998
Summary
Septilin, a herbal preparation, boosts the immune system by enhancing natural killer cell activity and macrophage function in mice. This supports its use for improving immunocompetence during illness.
Area of Science:
- Immunology
- Pharmacology
- Herbal Medicine
Background:
- The immune system plays a crucial role in combating diseases.
- Herbal preparations are increasingly explored for their immunomodulatory potential.
Purpose of the Study:
- To investigate the immunomodulatory effects of oral septilin administration.
- To evaluate septilin's impact on cellular and humoral immunity in mice.
Main Methods:
- Septilin was administered orally to normal and tumor-bearing mice.
- Key immune parameters assessed included natural killer cell activity, antibody-dependent cellular cytotoxicity, peritoneal macrophage activation, bone marrow cell proliferation, and antibody production.
Main Results:
- Septilin enhanced natural killer cell mediated cytotoxicity and antibody-dependent cellular cytotoxicity.
- Treatment activated peritoneal macrophages and increased bone marrow cell proliferation.
- Septilin boosted antibody-producing cells in the spleen and antibody-dependent complement-mediated cell lysis.
Conclusions:
- Septilin effectively enhances both cellular and humoral immune responses.
- The findings support the use of septilin for improving immunocompetence in various disease states.