Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between eugenol-related compounds and radicals

K Satoh1, H Sakagami, I Yokoe

  • 1Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.

Anticancer Research
|May 6, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal involvement of phosphatidylinositol 4-phosphate 5-kinase γ in differentiation of Z-bands and myofilament bundles as well as intercalated discs in mouse heart at mid-gestation.

Journal of anatomy·2024
Same author

Super-strong magnetic field-dominated ion beam dynamics in focusing plasma devices.

Scientific reports·2022
Same author

Impact of tocilizumab on N-terminal pro-brain natriuretic peptide levels in patients with active rheumatoid arthritis without cardiac symptoms.

Scandinavian journal of rheumatology·2018
Same author

Impact of biological treatment on left ventricular function and morphology in rheumatoid arthritis patients without cardiac symptoms, assessed by cardiac magnetic resonance imaging.

Scandinavian journal of rheumatology·2017
Same author

Boosting laser-ion acceleration with multi-picosecond pulses.

Scientific reports·2017
Same author

Blockade of the K<sub>ATP</sub> channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy.

Molecular psychiatry·2016

Eugenol and BHA effectively modulate free radicals, with eugenol showing higher activity. Dimerization significantly reduces this radical modulating and cytotoxic activity, suggesting potential dental applications for dimerized eugenol.

Area of Science:

  • Biochemistry
  • Free Radical Chemistry

Background:

  • Phenolic compounds like eugenol and BHA are known for their antioxidant properties.
  • Investigating radical modulation is crucial for understanding cellular processes and potential therapeutic applications.

Purpose of the Study:

  • To investigate the radical modulating activity of eugenol, BHA, and their respective dimers (bis-eugenol, bis-BHA).
  • To compare the radical scavenging abilities and cytotoxic effects of these compounds.

Main Methods:

  • Electron Spin Resonance (ESR) spectroscopy was employed to measure radical intensity.
  • Superoxide anion (O2-) scavenging activity was assessed using the hypoxanthine/xanthine oxidase system.

Main Results:

  • Eugenol demonstrated significant radical production and enhanced radical intensity in solutions.

Related Experiment Videos

  • BHA exhibited similar but weaker activity; both dimers (bis-eugenol, bis-BHA) were inactive.
  • Radical scavenging order was eugenol > bis-eugenol > BHA > bis-BHA.
  • Radical intensity correlated with cytotoxic activity.

    • Conclusions:

    • Eugenol and BHA are highly reactive with radicals, a property diminished upon dimerization.
    • Dimerized eugenol's reduced reactivity may have implications for its use in dental applications.