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Synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers
1Fuji-gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Shizuoka, Japan.
Bioorganic & Medicinal Chemistry
|May 6, 1998
Abstract:
The synthesis and vasorelaxant activity of 2-fluoromethylbenzopyran potassium channel openers are described. These (2-fluoromethyl) derivatives displayed smooth muscle relaxant activities comparable to or more potent than the corresponding 2-methyl analogues.