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New directions for neuronal migration
A L Pearlman1, P L Faust, M E Hatten
1Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA. apearl@cellbio.wustl.edu
Current Opinion in Neurobiology
|May 6, 1998
Abstract:
Analysis of genetic mutations that lead to abnormal migration and layer formation in the developing cerebral cortex of mice and humans has led to important new discoveries regarding the molecular mechanisms that underlie these processes. Genetic manipulation and experimental analysis have demonstrated significant tangential migrations of cortical neurons, some arriving from very distant noncortical sites.