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Related Experiment Videos

Target selection: invasion, mapping and cell choice

C E Holt1, W A Harris

  • 1Department of Anatomy, University of Cambridge, UK. ceh@mole.bio.cam.ac.uk

Current Opinion in Neurobiology
|May 6, 1998
PubMed
Summary
This summary is machine-generated.

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Axon targeting involves molecular cues that guide nerve growth into and within targets, preventing errors. This process may rely on axons comparing multiple molecular signals on target cells.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • Axon guidance is crucial for neural circuit formation.
  • Molecular cues regulate axon invasion and retention within target areas.
  • Understanding axon targeting mechanisms is key to neural development.

Purpose of the Study:

  • To explore the molecular mechanisms underlying axon targeting.
  • To investigate how axons navigate and select specific targets.
  • To elucidate the role of molecular gradients in axon guidance.

Main Methods:

  • Analysis of molecular concentration changes at target sites.
  • Observation of axon behavior in response to molecular cues.
  • Investigation of protein and carbohydrate involvement in axon targeting.

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Main Results:

  • Specific molecular gradients initiate target invasion.
  • Boundary molecules prevent axon exit from target regions.
  • Topographic and lamina-specific cues refine axon location.
  • Axon targeting may involve comparing relative molecular concentrations.

Conclusions:

  • Axon targeting is a complex process regulated by molecular gradients.
  • Proteins and carbohydrates play significant roles in guiding axons.
  • Axons might employ a combinatorial molecular recognition strategy for target selection.