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Superantigen production by Staphylococcus aureus in psoriasis

K Sayama1, K Midorikawa, Y Hanakawa

  • 1Department of Dermatology, Ehime University School of Medicine, Japan. sayama@m.ehime-u.ac.jp

Dermatology (Basel, Switzerland)
|May 6, 1998
PubMed
Summary

This study investigated Staphylococcus aureus superantigens in psoriasis patients. Results indicate superantigens are not essential for psoriasis but may trigger or worsen the condition in some individuals.

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Area of Science:

  • Dermatology
  • Immunology
  • Microbiology

Background:

  • T cell activation is crucial in psoriasis pathogenesis.
  • Psoriasis is proposed as a T-cell-mediated autoimmune reaction.
  • Bacterial superantigens may trigger this reaction.

Purpose of the Study:

  • To determine if psoriasis patients harbor superantigen-producing Staphylococcus aureus.
  • Investigated carriage on skin and throat.

Main Methods:

  • Analyzed skin and throat samples from 100 psoriasis patients.
  • Used Western blot analysis and polymerase chain reaction.
  • Screened for S. aureus producing exfoliative toxin, staphylococcal enterotoxin B, or toxic shock syndrome toxin 1.

Main Results:

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  • Superantigen-producing S. aureus was found in a small percentage of patients.
  • Identified in 5% on lesional skin, 4% on nonlesional skin, and 9% in the throat.
  • The majority of patients did not carry these bacteria.

Conclusions:

  • Superantigens are likely not essential for maintaining psoriasis disease activity.
  • May act as exacerbating or triggering factors for some patients.
  • Suggests a potential role in specific psoriasis cases.