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Related Experiment Videos

Ulcerative porokeratosis

T Watanabe1, T Murakami, H Okochi

  • 1Department of Dermatology, Tokyo University Branch Hospital, Japan. watanabet-der@h.u-tokyo.ac.jp

Dermatology (Basel, Switzerland)
|May 6, 1998
PubMed
Summary
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This case study details a man with lifelong porokeratosis that developed ulcerative changes during cardiovascular drug use. The findings highlight a rare presentation of porokeratosis with drug-induced exacerbation.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Porokeratosis is a group of chronic skin disorders characterized by abnormal keratinization.
  • Ulcerative variants of porokeratosis are uncommon, presenting diagnostic challenges.

Observation:

  • A 54-year-old male with a history of multiple annular plaques since infancy experienced new reddish, eruptive, and ulcerative changes.
  • These changes occurred over a 6-year period during nifedipine and nitroglycerin treatment, affecting the penis, scrotum, and legs.

Findings:

  • Histopathological examination revealed a classic cornoid lamella.
  • Additionally, findings included subepidermal band-like infiltrate, basal cell layer liquefaction degeneration, and keratinocyte coagulative necrosis.

Implications:

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  • This case suggests a potential link between nifedipine/nitroglycerin use and the exacerbation of porokeratosis into ulcerative lesions.
  • Further investigation into drug-induced changes in porokeratosis is warranted.