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Related Experiment Videos

Relationship between plasma and lymphocyte linoleate in multiple sclerosis

W M Tsang, J Belin, J A Monro

    Journal of Neurology, Neurosurgery, and Psychiatry
    |August 1, 1976
    PubMed
    Summary

    Multiple sclerosis patients showed decreased linoleate levels in lymphocytes. Lymphocyte linoleate levels correlated with plasma linoleate in humans and rats.

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    Area of Science:

    • Biochemistry
    • Immunology
    • Nutritional Science

    Background:

    • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
    • Alterations in lipid metabolism and fatty acid composition have been implicated in the pathogenesis of MS.
    • Linoleate, an essential omega-6 fatty acid, plays a role in cell membrane structure and function.

    Purpose of the Study:

    • To investigate the linoleate level in lymphocytes of patients with multiple sclerosis compared to control subjects.
    • To determine the relationship between dietary linoleate intake and lymphocyte fatty acid composition in rats.
    • To explore the correlation between lymphocyte and plasma linoleate levels in both humans and rats.

    Main Methods:

    • Lipid analysis of lymphocytes to quantify linoleate levels.

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  • Fatty acid profiling of lymphocyte total lipids.
  • Controlled dietary studies in rats with varying linoleate content.

    • Main Results:

    • A small but statistically significant decrease in linoleate levels was observed in lymphocytes from multiple sclerosis patients.
    • In rats, the percentage composition of lymphocyte fatty acids varied with dietary linoleate content.
    • A positive correlation was established between lymphocyte linoleate and plasma linoleate concentrations in both human and rat models.

    Conclusions:

    • Reduced lymphocyte linoleate may be associated with multiple sclerosis.
    • Lymphocyte fatty acid composition is influenced by dietary linoleate intake.
    • Plasma linoleate levels serve as a reliable indicator of lymphocyte linoleate status.