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Trypanosoma cruzi: IgG1 and IgG2b are the main immunoglobulins produced by vaccinated mice
A S Pyrrho1, J L Moraes, L M Peçanha
1Instituto de Biofísica Carlos Chagas Filho, CCS, UFRJ, Ilha do Fundão, Rio de Janeiro, Brazil.
Parasitology Research
|May 6, 1998
Abstract:
Mice vaccinated with CL-14, a non-infective and non-pathogenic clone isolated from Trypanosoma cruzi CL strain, become protected against lethal challenge by infective trypomastigotes. It has been shown that animals infected with T. cruzi show polyclonal activation of B lymphocytes with an early production of several non-specific immunoglobulins. Vaccinated mice, however, have an early production of antigen-specific IgG1 and IgG2b. Considering the lack of infectivity of CL-14, our data strongly suggest a role for IgG1 and IgG2b in protection to T. cruzi.