Antibacterial effects of some 1-substituted 1,2,4-triazoles

Seventeen synthetic 1-substituted 1,2,4-triazoles exerted a significant effect on the bacteria B. subtilis, S. aureus, E. coli and P. aeruginosa. The least sensitive to the effects of the triazoles was S. aureus. With all triazole derivatives and their combinations, B. subtilis and P. aeruginosa exhibited IC50 and MIC values several times higher than with ampicillin. The most effective triazoles have a N-phenyl ring or benzimidinoyl ring substituted with one or several chlorine atoms. The highest tested concentration of the three most effective triazoles influenced the specific growth rate.