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Urinary excretion of aquaporin-2 in term and preterm infants
H Tsukahara1, I Hata, K Sekine
1Department of Pediatrics, Fukui Medical School, Japan.
Early Human Development
|May 7, 1998
Abstract:
Aquaporin-2 (AQP-2) is a vasopressin-regulated water channel of the renal collecting duct and is excreted in human urine. We measured the urinary excretion of AQP-2 by radioimmunoassay in 14 term and 12 preterm infants aged 1 month. Excretion of AQP-2 was low compared with adults, and correlated significantly with urine osmolality in preterm infants. Our results demonstrate that AQP-2 water channels are expressed in the renal collecting duct of both term and preterm infants.