Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear receptors: structure, function and involvement in disease

S Tenbaum1, A Baniahmad

  • 1Genetisches Institut der Justus-Liebig Universität, Giessen, Germany.

The International Journal of Biochemistry & Cell Biology
|May 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.

Oncogene·2017
Same author

Atypical polycystic ovary syndrome--a genetic analysis.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2014
Same author

SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.

Oncogene·2013
Same author

Targeting heat shock proteins in prostate cancer.

Current medicinal chemistry·2013
Same author

Sirtuin family: a link to metabolic signaling and senescence.

Current medicinal chemistry·2010
Same author

Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells.

Oncogene·2008
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Nuclear hormone receptors regulate gene expression. Mutations in these receptors cause human syndromes and are linked to cancer progression, impacting hormonal response.

Area of Science:

  • Molecular Biology
  • Genetics
  • Endocrinology

Background:

  • Nuclear hormone receptors function as transcription factors, regulating gene expression in response to hormones.
  • Hormones modulate receptor activity, which bind to DNA via their DNA-binding domain on hormone response elements.
  • These receptors interact with lipophilic hormones, linking endocrine signaling to gene expression in target tissues.

Purpose of the Study:

  • To provide an overview of nuclear receptors and their naturally occurring mutant forms.
  • To examine the structural-functional relationships of these receptors and their mutants.
  • To understand the molecular-level effects of receptor mutations on human health.

Main Methods:

  • Review of existing literature on nuclear hormone receptors and their mutations.

Related Experiment Videos

  • Analysis of structural-functional relationships in receptor mutants.
  • Discussion of functional aberrations in specific nuclear receptors and the orphan receptor DAX1.

    • Main Results:

    • Identification of numerous naturally occurring mutations in nuclear hormone receptor genes.
    • Association of these mutations with human syndromes and cancer progression.
    • Detailed discussion of the molecular effects of mutations on receptor function.

    Conclusions:

    • Mutations in nuclear hormone receptors significantly impact human health, leading to hormonal response abnormalities, syndromes, and cancer.
    • Understanding the structural-functional basis of these mutations is crucial for comprehending their pathological effects.
    • This review highlights the critical role of nuclear hormone receptors in health and disease.