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Acute exacerbation of vasculitis during interferon-alpha therapy for hepatitis C-associated cryoglobulinaemia
A C Gordon1, J D Edgar, R G Finch
1Department of Microbiology and Infectious Diseases, Nottingham City Hospital, UK.
The Journal of Infection
|November 20, 1998
Abstract:
A significant, previously unreported, adverse reaction to interferon-alpha therapy is reported. Immediately after the commencement of low dose therapy a man with hepatitis-C associated cryoglobulinaemia developed a purpuric rash and a severe, reversible impairment of renal function. This observation may elucidate the immunopathogenesis of vasculitis.