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Updated: Aug 7, 2026
11:19
Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
Published on: July 7, 2010
Analysis and identification of imprinted genes
1Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, United Kingdom.
Methods (San Diego, Calif.)
|May 8, 1998
Summary
Genomic imprinting causes unequal gene expression from parental alleles in mammals. Recent studies reveal key roles of imprinted genes in development and their epigenetic regulation, aiding new gene discovery.
Area of Science:
- Genetics
- Epigenetics
- Developmental Biology
Background:
- Genomic imprinting leads to differential parental allele expression in mammals.
- Evidence for imprinting in mice arose from nuclear transplantation and uniparental inheritance studies.
- Approximately 20 imprinted genes have been identified in the last five years.
Purpose of the Study:
- To review the properties and epigenetic characteristics of imprinted genes.
- To discuss methods for analyzing imprinting effects and identifying new imprinted genes.
- To provide insights into the regulation of genomic imprinting.
Main Methods:
- Analysis of experimental materials designed to study imprinting.
- Review of established and state-of-the-art techniques for examining imprinted genes.
- Discussion of strategies for identifying novel imprinted genes.
Main Results:
- Imprinted genes play crucial roles in mammalian development.
- Epigenetic properties associated with imprinting have been described.
- Initial insights into imprinting regulation have been gained.
Conclusions:
- Genomic imprinting is a significant epigenetic phenomenon in mammals.
- Understanding imprinting is vital for comprehending development and gene regulation.
- Advanced techniques facilitate the study and identification of imprinted genes.
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