Calibration of a horizontal pendulum-type tablet breaking strength tester

Area of Science:

• Pharmaceutical technology
• Analytical chemistry
• Quality control

Background:

• Accurate tablet hardness testing is crucial for pharmaceutical product quality.
• Existing calibration methods for tablet hardness testers can be time-consuming.
• Motorized pendulum testers require reliable calibration for precise measurements.

Purpose of the Study:

• To develop and validate a rapid, simplified method for calibrating motorized pendulum tablet hardness testers.
• To assess the accuracy and precision of three new motorized pendulum testers.

Main Methods:

• Two calibrated force gauges were utilized.
• Two independent operators performed the calibration checks.
• The force gauge calibration method was employed to evaluate tester accuracy.

Main Results:

• The force gauge calibration method proved reliable for assessing tester accuracy.
• All three new motorized pendulum tablet hardness testers were found to be in calibration.
• The testers demonstrated reproducible results, indicating high precision.

Conclusions:

• The developed method offers a reliable and efficient approach for tablet hardness tester calibration.
• The new motorized pendulum testers meet accuracy and precision requirements for pharmaceutical applications.
• Standardized calibration ensures the integrity of tablet hardness data in quality control.