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Changes in intraocular pressure due to cycloplegia
J Velasco Cabrera1, P Eiroa Mozos, J Garcia Sanchez
1Department of Optics, Faculty of Sciences, University of Granada, Spain.
Summary
Chlorhydrate cyclopentolate 1% temporarily increases intraocular pressure (IOP) in healthy myopic individuals, peaking at 45 minutes. This effect on IOP is transient, returning to baseline within 24 hours.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Intraocular pressure (IOP) is a critical metric in ocular health.
- Myopia affects a significant portion of the population.
- Cyclopentolate is an anticholinergic medication used in ophthalmology.
Purpose of the Study:
- To investigate the effect of 1% chlorhydrate cyclopentolate on intraocular pressure (IOP) in healthy myopic subjects.
- To determine the time course of IOP changes following cyclopentolate administration.
Main Methods:
- Intraocular pressure (IOP) was measured in healthy myopic subjects.
- Measurements were taken before and at multiple time points after the administration of 1% chlorhydrate cyclopentolate (15, 30, 45, 60, 300 minutes, and 24 hours).
Main Results:
- A significant increase in IOP was observed at 30, 45, and 60 minutes post-administration (P < 0.05).
- The maximum IOP elevation occurred at 45 minutes.
- IOP returned to baseline levels by 24 hours, with no significant elevation at 15 or 300 minutes.
Conclusions:
- Cyclopentolate causes a transient, significant increase in IOP in healthy myopic individuals.
- The IOP elevation is temporary and resolves within 24 hours.
- Cyclopentolate is a useful tool for retinoscopy in patients with adequate anterior chamber depth and open angles.
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