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Related Experiment Videos

Left-right development in Xenopus and zebrafish

H J Yost1

  • 1Huntsman Cancer Institute Center for Children, University of Utah, Salt Lake City 84112-5330, USA.

Seminars in Cell & Developmental Biology
|May 8, 1998
PubMed
Summary
This summary is machine-generated.

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Vertebrate development features external symmetry and internal left-right asymmetry. Recent studies in Xenopus laevis and zebrafish explore how this asymmetry arises and aligns with other body axes.

Area of Science:

  • Developmental Biology
  • Embryology
  • Genetics

Background:

  • Vertebrates exhibit bilateral symmetry externally but significant left-right asymmetry internally.
  • Internal asymmetries are observed in major organ systems like the heart, circulatory, digestive, respiratory, and central nervous systems.
  • Understanding the origin of left-right asymmetry is crucial for developmental biology.

Purpose of the Study:

  • To investigate how left-right asymmetry arises from an initially symmetric state in vertebrates.
  • To determine how the left-right axis is aligned with other body axes (dorsal-ventral, anterior-posterior).
  • To identify key signaling molecules and cellular interactions regulating left-right development.

Main Methods:

  • Experiments conducted on Xenopus laevis (African clawed frog) embryos.

Related Experiment Videos

  • Experiments conducted on zebrafish embryos.
  • Analysis of signaling pathways and interactions with midline cells.

    • Main Results:

    • Identification of specific signaling molecules involved in establishing left-right asymmetry.
    • Elucidation of the role of midline cells in regulating left-right axis formation.
    • Insights into the coordination of left-right axis with dorsal-ventral and anterior-posterior axes.

    Conclusions:

    • Left-right asymmetry in vertebrates arises from complex signaling networks and cellular interactions.
    • Midline cells play a critical role in patterning the left-right axis.
    • These findings advance our understanding of fundamental developmental processes and potential congenital anomalies.