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Related Experiment Videos

Mitochondrial abnormalities in selenium-deficient myopathy

Y Osaki1, I Nishino, N Murakami

  • 1Department of Medicine and Geriatrics, Kochi Medical School, Nankoku-city, Kochi, Japan.

Muscle & Nerve
|May 8, 1998
PubMed
Summary

Selenium deficiency can cause myopathy, a muscle disorder, in patients receiving long-term parenteral nutrition. Mitochondrial abnormalities in muscle fibers are key to this condition, improving with selenium supplementation.

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Area of Science:

  • Biochemistry
  • Neurology
  • Pathology

Background:

  • Parenteral nutrition (PN) is a life-sustaining treatment for individuals unable to absorb nutrients orally.
  • Long-term PN can lead to micronutrient deficiencies, impacting cellular function.
  • Selenium is an essential trace element vital for antioxidant defense and mitochondrial function.

Observation:

  • A patient on long-term PN developed progressive muscle weakness.
  • Muscle biopsy revealed significant mitochondrial abnormalities, including depletion and enlargement, predominantly in type 2 muscle fibers.
  • These findings were associated with low selenium levels.

Findings:

  • The study identifies selenium-deficient myopathy as a complication of long-term parenteral nutrition.

Related Experiment Videos

  • Specific mitochondrial abnormalities in muscle fibers are directly linked to selenium deficiency.
  • Muscle strength and function improved following selenium repletion therapy.

    • Implications:

    • Highlights the importance of monitoring selenium levels in patients on long-term PN.
    • Suggests that selenium supplementation can reverse myopathy caused by deficiency.
    • Underscores the critical role of selenium in maintaining mitochondrial integrity and muscle function.