Are the capsaicin-sensitive structures of ventral medulla involved in the temperature response to endotoxin in rats?
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1Institute of Physiology, National Academy of Sciences, Minsk, Belarus, Russia. root@chel.minsk.by
Neuroscience Letters
|May 8, 1998
Abstract:
In chronic experiments on rats pretreated with bilateral microinjection of 25 nl 1% capsaicin to the caudal ventrolateral medulla under ketamine-xylazine-acepromazine anesthesia, an enhancement of the temperature response to intraperitoneal application of 3 microg/kg E. coli lipopolysaccharide as compared to animals who received vehicle to the caudal ventrolateral medulla was found. This is indicative of the involvement of the capsaicin-sensitive bulbar structures in thermoregulatory processes during endotoxemia.

