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Mycobacterium leprae binds to a 25-kDa phosphorylated glycoprotein of human peripheral nerve
L M Suneetha1, P R Satish, R J Korula
1Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, TN, India.
Neurochemical Research
|May 8, 1998
Abstract:
Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy.