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[Prospective study of the transit time in intestinal neuronal abnormalities]
B M Ure1, A M Holschneider, D Schulten
1Kinderchirurgische Klinik, Kinderkrankenhaus, Köln.
Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|January 1, 1997
Insights
Intestinal neuronal dysplasia type B or immature ganglia only prolonged transit time in 50% of children. However, hypoganglionosis and heterotopia caused severe bowel transport disorders, often requiring surgery.
Area of Science:
- Pediatric Gastroenterology
- Neurogastroenterology
- Developmental Biology
Context:
- Intestinal neuronal malformations are congenital disorders affecting gut motility.
- Accurate diagnosis is crucial for effective management and preventing complications.
- Intestinal transit-time studies are a key diagnostic tool.
Purpose:
- To evaluate the diagnostic utility of intestinal transit-time studies in children with various intestinal neuronal malformations.
- To correlate specific malformations with transit-time abnormalities.
- To assess the clinical implications of transit-time findings.
Summary:
- A prospective study assessed 106 children with intestinal neuronal malformations using intestinal transit-time studies.
- Prolonged transit time was observed in only 50% of children with intestinal neuronal dysplasia type B or immature ganglia.
- Hypoganglionosis and heterotopia of the submucous plexus were associated with severe transport disorders and often necessitated bowel resection.
Impact:
- Highlights the variable sensitivity of transit-time studies for different types of intestinal neuronal malformations.
- Underscores the severity of transport disorders in hypoganglionosis and heterotopia.
- Informs clinical decision-making regarding diagnostic approaches and surgical interventions for pediatric intestinal motility disorders.
Abstract:
In a prospective study 106 children with intestinal neuronal malformations underwent intestinal transit-time studies. In only 50% of the children with intestinal neuronal dysplasia type B or immature ganglia was the transit time prolonged. On the contrary, hypoganglionosis and heterotopia of the submucous plexus led to severe transport disorders with subsequent bowel resection.