The use of tetrazolium to determine hydronephrotic damage in human kidneys

A study detailing an assay for evaluating hydronephrotic damage is presented. We used nitroblue tetrazolium, which is reduced by intact renal tissue. When marked hydronephrotic damage has occurred little evidence of tetrazolium reducing activity is present. The clinical application has been helpful in determining the extent of damage and the subsequent need for removal of the kidney in question. When the test indicated functioning renal tissue a repair of the obstruction was performed with subsequent improvement in function.