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[Studies on absorption and excretion of cyclacillin granules (vastcillin granules 'Takeda') (author's transl)]
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Vastcillin granules, a cyclacillin (AC-PC) preparation, show excellent oral absorption in children. Peak blood levels were achieved rapidly, indicating favorable pharmacokinetics for pediatric use.
Area of Science:
- Pharmacology
- Pediatric Medicine
- Drug Development
Abstract:
Vastcillin granules 'Takeda', a cyclacillin (AC-PC) preparation for children were orally administered to nine children at a single dose of 10 mg/kg and its blood concentrations and urinary excretion were studied. From the results obtained, the following conclusions were obtained as to clinical dose and indications. (1) Absorption of AC-PC of Vastcillin granules is excellent . At 15 minutes after administration, 9.3 mcg/ml of AC-PC blood level was attained and its peak appeared 30 minutes after administration. The mean peak level was 17.6 mcg/ml.