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Prenatal diagnosis using fetal cells enriched from maternal blood
W Holzgreve1, E Di Naro, A M Garvin
1Department of Obstetrics and Gynecology, University of Basel, Schanzenstrasse 46, Basel, 4031, Switzerland. holzgreve@ubaclu.unibas.ch
Croatian Medical Journal
|May 12, 1998
Summary
Non-invasive prenatal diagnosis using fetal cells from maternal blood is advancing. New methods show promise but require further development for widespread clinical use, offering insights into pregnancy disorders.
Area of Science:
- Reproductive biology
- Genetics
- Obstetrics
Background:
- Prenatal diagnosis currently relies on invasive procedures like amniocentesis.
- Non-invasive methods using fetal cells in maternal blood are highly sought after.
- Fetal cell research offers potential insights into pregnancy complications.
Purpose of the Study:
- To review advancements in non-invasive prenatal diagnosis using fetal cells.
- To discuss the significance and challenges of current technologies.
- To explore new insights into fetal-maternal cell traffic and its relation to disorders.
Main Methods:
- Utilizing fluorescence in situ hybridization (FISH).
- Employing single-cell manipulation combined with polymerase chain reaction (PCR).
- Leveraging techniques common in preimplantation genetic diagnosis.
Main Results:
- Several new developments have been tested for fetal cell enrichment and analysis.
- Significant observations have been made regarding fetal-maternal cell trafficking.
- Potential for new understanding of conditions like preeclampsia and HELLP syndrome.
Conclusions:
- Non-invasive prenatal diagnosis via fetal cells is progressing but not yet broadly available.
- Further technological development is needed for widespread clinical application.
- Fetal-maternal cell traffic research may illuminate the pathogenesis of pregnancy disorders.