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[Changes in the ocular muscles in progressive scleroderma (author's transl)]

I Egerer, D Fanta

    Klinische Monatsblatter Fur Augenheilkunde
    |February 1, 1976
    PubMed
    Summary

    Generalized scleroderma can affect eye muscle movement. Histology revealed collagen increase and muscle degeneration in ocular muscles, similar to heart muscle changes in scleroderma patients.

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    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Pathology

    Context:

    • Generalized scleroderma is a multisystem autoimmune disease.
    • Ocular motility disorders are a potential, yet under-recognized, complication.
    • Previous research has not extensively detailed the ocular muscle pathology in scleroderma.

    Purpose:

    • To investigate the histopathological changes in the extraocular muscles of a patient with generalized scleroderma.
    • To correlate ocular muscle findings with cardiac histopathology in scleroderma.

    Summary:

    • One of 13 patients with generalized scleroderma exhibited ocular motility abnormalities.
    • Autopsy revealed significant interstitial collagen increase and degenerative changes in external ocular muscles.
    • These muscular changes closely mirrored histopathological findings observed in the myocardium of scleroderma patients.

    Impact:

    • Highlights a potential link between generalized scleroderma and ocular motility dysfunction.
    • Suggests that ocular muscle pathology may be a direct manifestation of the disease process.
    • Underscores the importance of considering ocular complications in the comprehensive management of scleroderma.

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